Dr. Joseph Kai-man KAM 

M.B., B.S., FRCPath

Clinical Associate Professor                                                                                                                                                                                                                                                                                  

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did_josephkam150.jpg 
Biography 
Dr. Kam joined the Stanley Ho Centre for Emerging Infectious Diseases in 2015. He obtained his Diplomate in American Board of Medical Microbiology, and then worked extensively in different medical and public health laboratories. He had served in the editorial boards of Journal of Clinical Microbiology and the Federation of European Microbiological Societies (FEMS) Immunology and Medical Microbiology.

Dr. Kam conducts teaching in clinical and public health microbiology at undergraduate and postgraduate levels. He has served as external consultant to national and international organizations for laboratory capacity building (in planning, design, training, monitoring) and continuous quality improvement.
Research Interests 
  • Molecular epidemiology using new laboratory tools, for tuberculosis;
  • Food and water borne pathogens with clinical and public health relevance;
  • Sexually transmitted diseases with local and regional significance;
  • Vector borne diseases that are emerging and/or re-emerging
Publications

Publications of 2015
  • Cheng VW, Leung KS, Kwok JS, Leung RK, Yang KY, Chan RC, KAM KM, Tsui SK. Phylogenetic and Structural Significance of Dihydrofolate Synthase (folC) Mutations in Drug-Resistant Mycobacterium tuberculosis. Microb Drug Resist. 2016 Apr 15. [Epub ahead of print]

  • Cheng CK, Cheung MK, Nong W, Law PT, Qin J, Ling JM, KAM KM, Cheung WM, Kwan HS. Next generation genome sequencing reveals phylogenetic clades with different level of virulence among Salmonella Typhimurium clinical human isolates in Hong Kong. BMC Genomics. 2015 Sep 14;16(1):688. doi: 10.1186/s12864-015-1900-y.

  • Li Q, Dong HY, Pang Y, Xia H, Ou XC, Zhang ZY, Li JC, Zhang JK, Huan ST, Chin DP, KAM KM, Zhao YL. Multicenter Evaluation of the Molecular Line Probe Assay for Multidrug Resistant Mycobacterium Tuberculosis Detection in China. Biomed Environ Sci. 2015 Jun;28(6):464-7. doi: 10.3967/bes2015.066.

  • You JH, Lui G, KAM KM, Lee NL. Cost-effectiveness analysis of the Xpert MTB/RIF assay for rapid diagnosis of suspected tuberculosis in an intermediate burden area. J Infect. 2015 Apr;70(4):409-14. doi: 10.1016/j.jinf.2014.12.015. Epub 2015 Jan 6.

  • Villarino ME, Scott NA, Weis SE, Weiner M, Conde MB, Jones B, Nachman S, Oliveira R, Moro RN, Shang N, Goldberg SV, Sterling TR; International Maternal Pediatric and Adolescents AIDS Clinical Trials Group; Tuberculosis Trials Consortium. Treatment for preventing tuberculosis in children and adolescents: a randomized clinical trial of a 3-month, 12-dose regimen of a combination of rifapentine and isoniazid. JAMA Pediatr. 2015 Mar;169(3):247-55. doi: 10.1001/jamapediatrics.2014.3158.

Publications of 2014
  • Ou X, Xia H, Li Q, Pang Y, Wang S, Zhao B, Song Y, Zhou Y, Zheng Y, Zhang Z, Zhang Z, Li J, Dong H, Chi J, Zhang J, KAM KM, Huan S, Jun Y, Chin DP, Zhao Y. A feasibility study of the Xpert MTB/RIF test at the peripheral level laboratory in China. Int J Infect Dis. 2015 Feb;31:41-6. doi: 10.1016/j.ijid.2014.09.011. Epub 2014 Oct 30.

  • Li L, Wong HC, Nong W, Cheung MK, Law PT, KAM KM, Kwan HS. Comparative genomic analysis of clinical and environmental strains provides insight into the pathogenicity and evolution of Vibrio parahaemolyticus. BMC Genomics. 2014 Dec 18;15:1135. doi: 10.1186/1471-2164-15-1135.

  • Zhang Z, Liu M, Wang Y, Pang Y, KAM KM, Zhao Y. Molecular and phenotypic characterization of multidrug-resistant Mycobacterium tuberculosis isolates resistant to kanamycin, amikacin, and capreomycin in China. Eur J Clin Microbiol Infect Dis. 2014 Nov;33(11):1959-66. doi: 10.1007/s10096-014-2144-5. Epub 2014 Jun 7.

  • Ou X, Li Q, Xia H, Pang Y, Wang S, Zhao B, Song Y, Zhou Y, Zheng Y, Zhang Z, Zhang Z, Li J, Dong H, Zhang J, KAM KM, Chi J, Huan S, Chin DP, Zhao Y. Diagnostic accuracy of the PURE-LAMP test for pulmonary tuberculosis at the county-level laboratory in China. PLoS One. 2014 May 1;9(5):e94544. doi: 10.1371/journal.pone.0094544. eCollection 2014.

  • De Beer JL, Ködmön C, van Ingen J, Supply P, van Soolingen D; Global Network for Molecular Surveillance of Tuberculosis 2010. Second worldwide proficiency study on variable number of tandem repeats typing of Mycobacterium tuberculosis complex. Int J Tuberc Lung Dis. 2014 May;18(5):594-600. doi: 10.5588/ijtld.13.0531.

  • KAM KM. Microscopic observation drug susceptibility (MODS): where are we going? Int J Tuberc Lung Dis. 2014 Feb;18(2):127. doi: 10.5588/ijtld.13.0777.

  • Zhang Z, Wang Y, Pang Y, KAM KM. Ethambutol resistance as determined by broth dilution method correlates better than sequencing results with embB mutations in multidrug-resistant Mycobacterium tuberculosis isolates. J Clin Microbiol. 2014 Feb;52(2):638-41. doi: 10.1128/JCM.02713-13. Epub 2013 Nov 27.
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  • Lam TK, Lau HY, Lee YP, Fung SM, Leung WL, KAM KM. Use of the INNO-LIA syphilis score assay in the resolution of discordant positive screening enzyme immunoassay results for the serological diagnosis of syphilis. Int J STD AIDS. 2014 Jan;25(1):52-6. doi: 10.1177/0956462413491938. Epub 2013 Jul 19.

Publications of 2013 

  • Chan Y, Yeung KH, Ho HF, Ho KM, Tin-Keung Lam E, Leung WL, KAM KM. Use of cerebrospinal fluid enzyme immunoassay for diagnosis of neurosyphilis. Int J STD AIDS. 2013 Dec 11;25(8):571-578.

  • Jiang GL, Chen X, Song Y, Zhao Y, Huang H, KAM KM. First proficiency testing of second-line anti-tuberculosis drug susceptibility testing in 12 provinces of China. Int J Tuberc Lung Dis. 2013 Nov;17(11):1491-4. doi: 10.5588/ijtld.13.0275.

  • Yip PC, KAM KM, Lam ET, Chan RC, Yew WW. In vitro activities of PNU-100480 and linezolid against drug-susceptible and drug-resistant Mycobacterium tuberculosis isolates. Int J Antimicrob Agents. 2013 Jul;42(1):96-7. doi: 10.1016/j.ijantimicag.2013.03.002. Epub 2013 May 15.
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  • Pang Y, Li Q, Ou X, Sohn H, Zhang Z, Li J, Xia H, KAM KM, O'Brien RJ, Chi J, Huan S, Chin DP, Zhao YL. Cost-effectiveness comparison of Genechip and conventional drug susceptibility test for detecting multidrug-resistant tuberculosis in China. PLoS One. 2013 Jul 23;8(7):e69267. doi: 10.1371/journal.pone.0069267

  • Wang X, Tang NL, Leung CC, KAM KM, Yew WW, Tam CM, Chan CY. Association of polymorphisms in the Chr18q11.2 locus with tuberculosis in Chinese population. Hum Genet. 2013 Jun;132(6):691-5. doi: 10.1007/s00439-013-1282-7. Epub 2013 Mar 3.

  • Pang Y, Xia H, Zhang Z, Li J, Dong Y, Li Q, Ou X, Song Y, Wang Y, O'Brien R, KAM KM, Chi J, Huan S, Chin DP, Zhao Y. Multicenter evaluation of genechip for detection of multidrug-resistant Mycobacterium tuberculosis. J Clin Microbiol. 2013 Jun;51(6):1707-13. doi: 10.1128/JCM.03436-12. Epub 2013 Mar 20.

  • Lo MW, Mak SK, Wong YY, Lo KC, Chan SF, Tong GM, Lo KY, Wong PN, Tse CW, KAM KM, Wong AK. Atypical mycobacterial exit-site infection and peritonitis in peritoneal dialysis patients on prophylactic exit-site gentamicin cream. Perit Dial Int. 2013 May-Jun;33(3):267-72. doi: 10.3747/pdi.2011.00184. Epub 2012 Oct 2.

  • Wong CK, Hung P, KAM KM. Development of an ICR mouse bioassay for toxicity evaluation in neurotoxic poisoning toxins-contaminated shellfish. Biomed Environ Sci. 2013 May;26(5):346-64. doi: 10.3967/0895-3988.2013.05.004.

Publications of 2012 

  • Leung EC, Leung CC, KAM KM, Yew WW, Chang KC, Leung WM, Tam CM. Transmission of multidrug-resistant and extensively drug-resistant tuberculosis in a metropolitan city. Eur Respir J. 2013 Apr;41(4):901-8. doi: 10.1183/09031936.00071212. Epub 2012 Aug 9.

  • Leung KL, Yip CW, Tang HS, Lai YW, Lam TK, KAM KM. A pilot external quality assurance programme for line-probe assay detection of anti-tuberculosis drug resistance. Int J Tuberc Lung Dis. 2013 Feb;17(2):262-6. doi: 10.5588/ijtld.12.0533. Epub 2012 Dec 14.

  • Xia H, Song YY, Zhao B, KAM KM, O'Brien RJ, Zhang ZY, Sohn H, Wang W, Zhao YL. Multicentre evaluation of Ziehl-Neelsen and light-emitting diode fluorescence microscopy in China. Int J Tuberc Lung Dis. 2013 Jan;17(1):107-12. doi: 10.5588/ijtld.12.0184.

  • Cheung MK, Lam WY, Fung WY, Law PT, Au CH, Nong W, KAM KM, Kwan HS, Tsui SK. Sputum microbiota in tuberculosis as revealed by 16S rRNA pyrosequencing. PLoS One. 2013;8(1):e54574. doi: 10.1371/journal.pone.0054574. Epub 2013 Jan 24.

  • Li L, Cheng CK, Cheung MK, Law PT, Ling JM, KAM KM, Cheung WM, Kwan HS. Draft genome sequence of Salmonella enterica serovar Typhimurium ST1660/06, a multidrug-resistant clinical strain isolated from a diarrheic patient. J Bacteriol. 2012 Nov;194(22):6319-20. doi: 10.1128/JB.01593-12.
 
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