Professor Maggie Haitian WANG (王海天教授)

BSc (HKUST), PhD (HKUST)
Assistant Professor               

Office address: Centre for Clinical Research and Biostatistics, 5/F,                                                                
JC School of Public Health and Primary Care Buliding, Prince of Wales Hospital, Shatin  

Websites: Maggie at CCRB, CCRB-Statistical Genetics (CCRB-Statgene)
Email: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it                                           

• MEDP6001 Joint University Course in Biomedical Sciences
• MEDP6002/6003 Introduction to Biostatistics to Faculty of Medicine graduate students
• BIOS5001 Biostatistics I
• BIOS5002 Linear Models
• BIOS5003 Categorical data analysis
• BIOS6001 Topics in Linear Models
• BIOS6005 Pharmaceutical Bioinformatics
• INFD5006 Infectious Diseases Modeling

• Statistical Genetics and Bioinformatics: We develop new statistical methods and algorithms that provide accurate measure for gene-gene or gene-environmental interactions effects, and incoporate interactions in disease classification problem. For NGS data, we develop new rare variant association test and algorithm that can enhance the power for low frequency and rare variant testing. The overall target is to offer novel and powerful statistical methods to reveal the secret of human genetics data. Representative publications: Bioinformatics 2017; Nucleic Acids Research 2016, IF=9.2


• Infectious diseases genetic epidemiology: We are interested to model the pattern of infectious disease epidemics at population level and genetic level, and to model genetic sequence evolution. Methods involved: distance of biological sequences and phylogenetic trees. Diseases worked: seasonal and pandemic influenza, new emerging virus (H7N9), norovirus, Hand-foot-mouth disease. Representative publications:  Journal of Infection 2015, 2016, IF=4.44

• Statistical collaborations with clinical and biomedical scientists:  Genetics examples: selected seven microRNAs associated with gastric cancer progression from seven hundreds miRNAs which are later validated in-vitro and in-vivo. Epidemiology example: statistical analysis of multi-stratified and clustered sampling data sets, extreme proportion confidence interval, propensity score, etc. Representative publications: Oncogene 2015; Cancer Research 2014, IF=9.2

• W-test: for main effect and SNP-SNP interaction association testing in GWAS data (software page)
• ZFA: for rare variant association tests in NGS data (upcoming...)

• "Genetic Test, Risk Prediction Model, and Genetic Counselling", with Haoyi Weng, Book Title: Translational Informatics in Smart Healthcare, Springer, To Appear. 

• Xiaoxuan Xia, PhD student, 2016.9 - Current, Co-supervised with Prof. Benny Zee. Area: Complex disease prediction
• Haoyi Weng, PhD student, 2015.9 - Current, Co-supervised with Prof. Benny Zee. Area: Rare variant tests
• Ruoting Men, PhD student, 2015.9 - Current, Co-supervised with Prof. Benny Zee. Area: Chemoinformatics
• Rui Sun, PhD student, 2013.9 - Current, Co-supervised with Prof. Benny Zee. Area: Interaction effect tests

• 2015.5.1 - 2016.4.30  PI, CUHK Direct grant. The W-test for complex disease risk profiling in GWAS incorporating interaction effects among genes. 41,000 HKD.
• 2015.1- 2018.12  PI, 国家自然科学基金 – 面上项目 National Science Foundation of China (NSFC) – General Project. Tracking pattern of amino acids underlying seasonal influenza epidemic. 700,000 RMB.
• 2015.1– 2017.12  国家自然科学基金 – 青年基金. PI, NSFC – Youth. A bioinformiatic method to detect interaction effect among genes and its application clinical diagnosis. 220,000 RMB.
• 2014.1 - 2015.12  PI, RGC - General Research Fund (GRF), A fast and non-invasive testing method for renal function and diabetes through selected ion flow tube mass spectrometry (SIFT-MS). 779,000 HKD
• 2013.3 - 2014.4  PI, CUHK Direct Grant, Identifying gene-environment interactions in GWAS considering non-linear age effect. 46,500HKD
• 2012.3 - 2013.3  PI, CUHK Direct Grant, the Identification of Disease Associated Markers with Interaction Effects in Microarray Datasets. 60,000HKD

• Maggie Haitian Wang*, Haoyi Weng (co-first), Rui Sun, Jack Lee, Ka Chun Chong, William K.K. Wu, Benny Chung-Ying Zee* (2017) A Zoom-Focus Algorithm (ZFA) to locate the optimal testing region for rare variant association tests. Bioinformatics. DOI:10.1093/bioinformatics/btx130 (IF=5.76, 3/56, Area: Statistical Genetics)
  
  
• Maggie Haitian Wang*, Billy Chang, Rui Sun, Inchi Hu, Marc Ka Chun Chong, Benny Chung-Ying Zee*(2017), A Stratified Polygenic Risk Prediction Model with Application on CAGI Bipolar Disorder Sequencing Data. Human Mutation. (IF=5.08, Area: Statistical Genetics)
  
  
• Maggie Haitian Wang*, Steven YF Lau+, Chloe Kwok, Ka Chun Chong, Maria Lai, Anthony HY Chung, Chung Shun Ho, Cheuk-Chun Szeto, Benny Chung-Ying Zee (2017). Estimation of clinical parameters of chronic kidney disease (CKD) by exhaled breath full-scan mass spectrometry data and Iterative PCA with Intensity Screening (IPS) algorithm. Journal of Breath Research 10 (2017) 046004. (IF=4.17. 9/58, Area: Mass spectrometry data analysis)
  
  
• Ka Chun Chong, Chi Zhang, Benny Chung Ying Zee, Tongyong Luo, Lei Wang, Greta Chun Huen Tam, Katherine Min Jia, Riyang Sun, Maggie Haitian Wang^*, Xuhua Guan (2017) Interpreting the transmissibility of measles in two different post periods of supplementary immunization activities in Hubei, China. Vaccine. 
  
  
• Marc Ka Chun Chong, Benny Chung Ying Zee, Maggie Haitian Wang^* (2017) A statistical method utilizing information of imported cases to estimate the transmissibility for an influenza pandemic. BMC Medical Research Methodology.
  
  
• Ruoting Men, Maoyao Wen, Mingyue Zhao, Xuelian Dan, Zongze Yang, Wenchao Wu, Maggie Haitian Wang, Xiaojing Liu, Li Yang (2017) MircoRNA-145 promotes activation of hepatic stellate cells via targeting krüppel-like factor 4. Scientific Reports
  
  
• Wu WKK, Li X, Wang X, Dai RZW, Cheng ASL, Wang MHT, Kwong T, Chow TC, Yu J, Chan MTV, Wong SH (2016). Oncogenes without a neighboring tumor-suppressor gene are more prone to amplification. Molecular Biology and Evolution. IF = 13.65  

• Maggie Haitian Wang*, Rui Sun, Junfeng Guo, Haoyi Weng, Jack Lee, Inchi Hu, Pak Sham and Benny C.Y. Zee* (2016).  A fast and powerful W-test for pairwise epistasis testing. Nucleic Acids Research. (IF=9.2, Area: Statistical Genetics)
  
  
• Rui Sun, Haoyi Weng, Inchi Hu, Junfeng Guo, William K.K. Wu, Benny Chung-Ying Zee, Maggie Haitian Wang* (2016) A W-test collapsing method for rare variant association testing in exome sequencing data. Genetic Epidemiology. DOI: 10.1002/gepi.22000  (Area: Statistical Genetics)
  
  
• Maggie Haitian Wang, Ka Chun Chong, Hau Yin Chung, Malina Storer, John Pickering, Zoltan Endre, Steven Lau, Chloe Kwok, Maria Lai, Benny Zee (2016). Use of a Least Absolute Shrinkage and Selection Operator (LASSO) Model to Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) Analysis of Exhaled Breath to Predict the Efficacy of Dialysis. Journal of Breath Research 10 (2016) 046004. (IF=4.17, Area: Mass Spectrometry Methodology)

• Yaqing He, Linjie Zou, Ruoting Men, Wenbo Xu, Benny Chung-Ying Zee, Hong Yang, Xiangjie Yao，Long Chen, Huixia Xian, Hailong Zhang, Min Luo, Jinquan Cheng, Hanwu Ma，Qianjin Feng, Yun Huang, Yujie Wang, Eng-kiong Yeoh, Benny Chung-Ying Zee, Yuanping Zhou, Ming-Liang He, and Maggie Haitian Wang* (2016) Genetic evolution of EV71 in Shenzhen China from 1998 to 2013. Journal of Infection. Accepted. IF=4.44.  (Area: Genetic Epidemiology)

• Ho J, Yu J, Wong SH, Zhang L, Liu X, Wong WT, Leung CCH, Choi G, Wang MH, Gin T, Chan MTV*, Wu WKK* (2016). Autophagy in sepsis: Degradation into exhaustion? Autophagy. IF= 11.75
  
  
• Chunli Wu*, Maggie Haitian Wang*(co-first), Xing Lu, Ka Chun Chong, Jason He, Chun Yip Yau, Mark Hui, Xiao-wen Cheng, Hsiangfu Kung, Benny Chung Ying Zee, Renli Zhang and Mingliang He (2016) Concurrent epidemics of influenza A/H3N2 and A/H1N1pdm in Southern China: a serial cross-sectional study. Journal of Infection. Accepted. IF=4.44. (Area: Genetic Epidemiology)
  
  
• Zhenyu Xua, Jing Shen, Maggie Haitian Wang, Tao Yi, Yangyang Yu, Yinxin Zhu, Bo Chen, Jianping Chen, Longfei Li, Minxing Li, Jian Zuo, Hui Jiang, Dexi Zhou, Jiajie Luan & Zhangang Xiao (2016) Comprehensive molecular profiling of the B7 family of immune-regulatory ligands in breast cancer. OncoImmunology. DOI: 10.1080/2162402X.2016.1207841
  
  
• Hon KL, Kung JSC, Wang Maggie, Leung TF (2016). Clinical scores of sleep loss/pruritus and antihistamine/topical corticosteroid usage for childhood eczema. British Journal of Dermatology. Accepted. IF=4.3
  
  
• Biao Zhou, Xuefen Su, Danting Su, Fangfang Zeng, Maggie Haitian Wang, Lichun Huang, Enshan Huang, Yibo Zhu, Dong Zhao, Denghua He, Xuhui Zhu, Engkiong Yeoh, Ronghua Zhang and Gangqiang Ding (2016) Dietary intake of manganese and the risk of the metabolic syndrome in a Chinese population. British Journal of Nutrition.
  
  
• Jeffery Ho, Lin Zhang, Xiaodong Liu, Sunny H Wong, Maggie H T Wang, Benson W M Lau, Shirley P C Ngai, Hung Chan, Gordon Choi, Czarina C H Leung, Wai T Wong, Sharon Tsang, Tony Gin, Jun Yu, Matthew T V Chan, William K K Wu. (2016) Pathological role and diagnostic value of endogenous host defense peptides in adult and neonatal sepsis: a systematic review. Shock 2016 Dec 9. Epub 2016 Dec 9.
  
  
• Jeffery Ho, Hung Chan, Sunny H. Wong, Maggie H. T. Wang, Jun Yu, Zhangang Xiao, Xiaodong Liu, Gordon Choi, Czarina C. H. Leung, Wai T. Wong, Zheng Li, Tony Gin, Matthew T. V. Chan and William K. K. Wu (2016) The involvement of regulatory non-coding RNAs in sepsis: a systematic review. Critical Care 20 (1), 383.
  
  
• Rui Sun, Benny C.Y. Zee, Maggie Haitian Wang* (2016) A clustering approach to identify rare variants associated with hypertension. BMC Proc. 2015;9 Suppl 8:S16.

• Marc Chong, Xiaoxiao Wang, Sheland Liu, Jian Cai, Xuefen Su, Benny Chung-Ying Zee, Maggie Haitian Wang*, Enfu Chen* (Co-corresponding) (2015) Interpreting the transmissibility of the avian influenza A (H7N9) infection from 2013 to 2015 in Zhejiang province, China. Epidemiology and Infection. Accepted. 

• Weiqin Yang, Myth T. Mok, May S. M. Li, Wei Kang, Maggie Haitian Wang, Anthony W. Chan, Jian-Liang Chou, Jie Chen, Enders K. W. Ng, Ka F. To, Jun Yu, Michael W.Y. Chan, Francis K. L. Chan, Joseph J. Y. Sung, Alfred S. L. Cheng (2015) Epigenetic silencing of GDF1 disrupts SMAD signaling to reinforce gastric cancer development. Oncogene. IF=8.6
  
  
• Wei-Qin Yang, May S.M. Li, Wei Kang, Li-Han Zeng, Haitian Wang, Anthony W. Chan, Enders K.W. Ng, Ka F. To, Francis K.L. Chan, Jun Yu, Michael W.Y. Chan, Joseph J.Y. Sung, Alfred S.L. Cheng (2015). Reactivation of Growth/Differentiation Factor 1 Contributes to the Chemopreventive Effect of 5-aza-2’deoxycytidine in Gastric Cancer. Clinical Gastroenterology and Hepatology, 1(13), 214. IF=7.6


• Maggie H. Wang, Kelvin Tsoi, Xin Lai, Marc Chong, Tian Zheng, Shaw-Hwa Lo, Benny Zee and Inchi Hu (2015) Two screening methods for genetic association study with application on psoriasis microarray data sets. IEEE International Congress on Big Data.   (Area: Statistical Genetics)


• Marc Chong, Kelvin Tsoi, Maggie H. Wang, Benny Zee, Fung Hong, EK Yeoh, Eliza Wong, Carrie Yam, Patsy Chau, Colin Graham. Using a System Dynamic Model to Evaluate the Patient Flow in an Emergency Department of Hong Kong. IEEE International Congress on Big Data. Accepted. 


• Xin Lai, Liu Liu, Paul B.S. Lai, Kelvin Tsoi, Maggie H. Wang, Ka Chun Chong and Benny Zee.  Risk-adjusted Monitoring Method for Surgical Data Methodology for Data Analytics (Work in Progress) IEEE International Congress on Big Data. Accepted.


• Ka Chun Chong, William Goggins, Benny Chung Ying Zee, Maggie Haitian Wang (2015) Identify Meteorological Drivers for the Seasonal Variations of Influenza Infections in a Subtropical City, Hong Kong.  International Journal of Environmental Research and Public Health. ijerph-69059; doi: 10.3390/ijerph120201560 
  
  
• Bin Jiao, Xiaoyan Liu, Lin Zhou, Maggie Haitian Wang, Yafang Zhou, Tingting Xiao, Weiwei Zhang, Rui Sun, Mary Miu Yee Waye, Beisha Tang, Lu Shen (2015) Polygenic Analysis of late onset Alzheimer Disease from mainland China. PLoS ONE. Accepted.

• Jin Shen, William K.K. Wu, Maggie H. Wang, Ka F. To, Yangchao Chen, Zhanggang Xiao, May S.M.Li, May S.M. Li, Joanna H. Tong, Wei Kang, Lin Zhang, Lin Wang, Lan Lu, Ruby L.Y. Chan, Jun Yu, Francis K.L. Chan, Joseph J.Y. Sung, Alfred S.L. Cheng, Chi H. Cho (2014) Epigenetic silencing of miR-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-induced gastric carcinogenesis. Cancer Research. canres.1301.2014. IF=9.2


• Maggie Haitian Wang, Jiexin Li, Venus Yeung, Benny Zee, Mary Waye, Suzanne Ho (2014) Gene-gene interactions infer strong risk for type 2 diabetes, obesity and hypertension in Hong Kong Women on candidate genes. Meta Gene. 10.1016/j.mgene.2014.04.010


• Lai He*, Jin Zhao*, Maggie Haitian Wang*(joint first author), Kenny KY Siu, Yong-Xia Gan, Lin Chen, Albert WN Leung, Hsiang-Fu Kung,  Benny Zee, Zheng-Rong Yang, Ming-Liang He (2014) Interleukin-27 (IL-27) differentially associated with HIV viral load and CD4+ in HIV monoinfected and HIV/HCV coinfected groups . PLoS ONE, V9(5), e96792. IF=4.24


• Maggie Haitian Wang, Chien-Hsun Huang, Tian Zheng, Shaw-Hwa Lo and Inchi Hu (2014) A two-stage treatment of longitudinal data incorporating environmental factors to identify associated SNPs to high blood pressures.  BMC Proceedings. 8(Suppl 1):S62 


• Michael Agne, Chien-Hsun Huang, Inchi Hu, Maggie Haitian Wang, Tian Zheng, and Shaw-Hwa Lo (2014) Considering Interactive Effects in the Identification of Influential Regions with Extremely Rare Variants via Fixed Bin Approach. BMC Proceedings. 8(Suppl 1):S7


• Ruixue Fan, Chien-Hsun Huang, Inchi Hu, Maggie Haitian Wang, Tian Zheng and Shaw-Hwa Lo (2014) A Partition-based Approach to Identify Gene-Environment interactions in Genome Wide Association Studies.  BMC Proceedings. 8(Suppl 1):S60


• XIE Chen; WANG Zhijun; WANG Charles; XU Jun; WEN Zhining; WANG Haitian; SHI Leming; CHOW S.s. Moses; HUANG Ying and ZUO Zhong. (2013) Utilization of Gene Expression Signature for Quality Control of Traditional Chinese Medicine Formula Si-Wu-Tang. The AAPS Journal vol.15 no.3, pp.884-892. United States of America, 2013.05.24. IF=5.71.


• Chun-Li Wu*, Juan Lu*, Maggie Haitian Wang**(joint first author), Xing Lv, Ying Chen, Xin Wang, Hsiang-fu Kung, Benny Zee, Xiao-wen Cheng, Ming-Liang He (2013) Cross sectional survey of influenza antibodies before and during the 2009 pandemic in Shenzhen, China. PLoS ONE 8(1): e53847. doi:10.1371/journal.pone.0053847. IF=4.24.


• Maggie Haitian Wang, Shaw-Hwa Lo, Tian Zheng and Inchi Hu (2012) A Classification Method Incorporating Interactions among Variables for High-dimensional Data. Bioinformatics (2012) 28 (21): 2834-2842 (Area: Statistical Genetics)


• Nathan Tintle, Hugues Aschard, Inchi Hu, Nora Nock, Haitian Wang and Elizabeth Pugh (2011) Inflated Type I Error Using Aggregation Methods for Rare Variant Data. Genetic Epidemiology, 35, S8. IF=3.48.  


• Haitian Wang, Chien-Hsun Huang, Tian Zheng, Shaw-Hwa Lo and Inchi Hu (2011) New Insights on Old Methods in Identifying Causal Rare Variants, BMC Proceedings. 5 Suppl 9: S50.


• Michael Agne, Chien-Hsun Huang, Inchi Hu, Haitian Wang, Tian Zheng and Shaw-Hwa Lo (2011) Identifying influential regions in extremely rare variants using a fixed-bin approach, BMC Proceedings. 5 Suppl 9: S3.

• 2017 - , Communication committee member, International Genetic Epidemiology Society (IGES)