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Professor Benjamin Hon-kei YIP (葉漢基教授)

BRBS, MS (Swe), PhD (Karolinska Inst, Swe) 


Assistant Professor 

JC School of Public Health and Primary Care


ORCID: 0000-0002-4749-7611


Division of Family Medicine and Primary Health Care


Dr. Yip joined the School of Public Health and Primary Care (SPHPC) of the Chinese University of Hong Kong (CUHK) in 2011, and he is currently an Assistant Professor. In 2008, he received his Doctor of Philosophy (PhD) degree from Karolinska Institutet, Sweden. His thesis was to develop statistical methods for estimating random effects models with the purpose of estimating variance components for disease liability and correlations in pedigree data. Together with his PhD supervisor, Professor Yudi Pawitan, they examined the co-morbidity and liability between schizophrenia and bipolar disease in a large population based sample⁠. This research ended one of the most persistent debate in psychiatry which is whether schizophrenia and bipolar disorder are the clinical realizations of entirety different versus identical etiological process (Lancet 2009). He continued to develop and refine these methods, as evident by recent publications in top international peer review manuscripts⁠ (JAMA Psychiatry 2019 , Biological Psychiatry 2018, 2020).

In parallel with his continued engagement at Karolinska Institutet on genetic epidemiological research, he is serving as the lead statistician in various clinical studies, ranging from clinical trials to cohort studies, steering committee member of Domestic Health Account (FHB), member of service learning committee (Chung Chi College), and a leading member of one WUN working group on integrated care model for multimorbidity. He is teaching health economics both on bachelor and post-graduate level. He is currently supervising four PhD students. Previously, he supervised/co-supervised four other graduated PhD students.

Dr. Yip is serving as the principal investigators or as the lead biostatistician in numerous funded projects (see below). He has 83 academic articles (up-to-date 20/07/2020) with a h-index of 17. For a complete publications list please see

Research Interest and On-going Projects

  • Mental Health

    • Genetic Epidemiology of Autism Spectrum disorder

    • Mindfulness as an intervention to improve bracing compliance among AIS patients (GRF U616144, PI)

  • Health Economics

    • Cost of Illness of Dementia (HMRF MD18614, Co-PI).

    • Cost-effectiveness of Volunteer-based Home care program (HCPS MD18323, Co-Investigator)

  • Primary Care Clinical Trials

    • The Low-Concentration Atropine for Myopia Progression (LAMP) trial (GRF U911034, Co-Investigator).

    • Mind-Body Physical Exercise for patients with mild cognitive impairment trial (HMRF MD19479, Co-Investigator)



Selected Publications

(^PhD student, *Corresponding Author, ~Equal contribution) 


  1. Bai D^, Yip BHK, Windham GC, Sourander A, Francis R, Yoffe R, Glasson E, Mahjani B, Suominen A, Leonard H, Gissler M, Buxbaum JD, Wong K, Schendel D, Kodesh A, Breshnahan M, Levine SZ, Parner ET, Hansen SN, Kharrazi M, Hultman C, Reichenberg A, Sandin S. Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort. JAMA Psychiatry. 2019 [doi:10.1001/jamapsychiatry.2019.1411 Epub ahead of print]

  2. Yip BHK*, Bai D, Mahjani B, Klei L, Pawitan Y, Hultman CM, Grice DE, Roeder K, Buxbaum JD, Devlin B, Reichenberg A, Sandin S. Heritable Variation, With Little or No Maternal Effect , Accounts for Recurrence Risk to Autism Spectrum Disorder in Sweden. Biological Psychiatry. 2018;83:589–97.

  3. Yip BHK*, Leonard H, Stock S, Stoltenberg C, Francis RW, Gissler M, Gross R, Schendel D, Sandin S. Caesarean section and risk of autism across gestational age: a multi-national cohort study of 5 million births. International Journal of Epidemiology. 2017;46:429-439.

  4. Lichtenstein P, Yip BH, Björk C, Pawitan Y, Cannon TD, Sullivan PF, Hultman CM. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. The Lancet. 2009;373:234-9.

  5. Yip BH, Pawitan Y, Czene K. Parental age and risk of childhood cancers: A population-based cohort study from Sweden. International Journal of Epidemiology. 2006;35:1495-503

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