Centre for Occupational and Environmental Health Studies

Professor Shelly Lap-ah TSE (謝立亞教授)
Director, Centre for Occupational and Environmental Health Studies; and
Head, Division of Occupational & Environmental Health;
Associate Professor

Honorary Advisor, FM/GOPC KCC, Hospital Authority
Advisor for Clinical Epidemiology, Hong Kong Medical Journal
Visiting Professor, Nanjing Medical University, China 

Tel: (852) 22528791
Fax: (852) 26063500
Email: shelly@cuhk.edu.hk


Messages from the COEHS Director


The missions of the COEHS are to conduct excellent research, teaching and training, as well as provide valuable services to the community in terms of occupational and environmental health.



Professor Shelly Tse now heads the Center for Occupational and Environmental Health Studies (COEHS) and the Division of Occupational and Environmental Health, JC School of Public Health and Primary Care. Her major expertise is in the area of occupational and environmental cancer etiology, particularly for lung cancer and breast cancer, as well as large occupational cohort of night shift work in China. Prof. Shelly Tse is the principal investigator of a GRF/RGC project about nightshift work and female breast cancer (2011-2013), two NSFC projects (National Natural Science Foundation of China) about nightshift work, two PCFB (Pneumoconiosis Compensation Fund Board) funded projects, two Occupational Safety and Health Council (OSHC) funded projects, and two NCI/NIH funded projects about breast cancer, molecular epidemiology, and environmental exposures. Moreover, Shelly Tse has close collaborations with the SYNERGY Project of lung cancer (led by IARC/WHO).



  • National Excellence in Science and Technology of the Shenzhen Virtual University Park (2013), awarded by Shenzhen Municipal Science and Technology Innovation Council, China

  • The Most Promising Young Researcher Award (2012), JC School of Public Health and Primary Care, the Chinese University of Hong Kong

  • Global Scholarship Programme for Research Excellent – CNOOC Grants and trained in Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, U.S., Department of Health and Human Services, National Cancer Institute, National Institutes of Health, U.S.A. in 2012.

  • Best Project Award for the Academic Year 2006/2007 by Occupational Safety & Health Council in Hong Kong

  • Best Project Awards for the Academic Year 2002/2003 by Occupational Safety & Health Council in Hong Kong

  • Honor certificate (National Stroke Prevention) by China Medical Science College in 1998

  • WHO Awards for Chinese young professional in the mental health and Neuroscience in 1997.


Recent Representative Publications


  1. Hyuna Sung, Philip S. Rosenberg, Wan-Qing Chen, Mikael Hartman, Wei-yen Lim, Kee Seng Chia, Oscar Wai-kong Mang, Chun-Ju Chiang, Daehee Kang, Lap-ah TSE, William F. Anderson, Xiaohong R. Yang. Female breast cancer incidence among Asian and Western populations: more similar than expected. Journal of National Cancer Institute (provisionally accepted)

  2. Tse Lap Ah, Yu Ignatius TS, Qiu Hong, Leung Chi Chiu. Joint Effects of Smoking and Silicosis on Diseases to the Lungs. PloS One 2014;9(8): e104494

  3. A Meta-analysis on Dose-response Relationship Between Night Shift Work and the Risk of Breast Cancer. Annals of Oncology 24 (11): 2724–2732. 2013.11. [Corresponding]

  4. QIU, Hong, YU Tak Sun Ignatius, TSE Lap Ah, TIAN Linwei, WANG Xiaorong and WONG Tze Wai. "Is Greater Temperature Change within a Day Associated with Increased Emergency Hospital Admissions for Heart Failure?". Circulation: Heart Failure 6 (5): 930–935. 2013.09

  5. YU Tak Sun Ignatius, QIU, Hong, WANG Xiaorong, TIAN Linwei and TSE Lap Ah. "Synergy between Particles and Nitrogen Dioxide on Emergency Hospital Admissions for Cardiac Diseases in Hong Kong". International Journal of Cardiology 168 (3): 2831–2836. 2013.10.

  6. TSE Lap Ah, YU Tak Sun Ignatius. Re: The Diesel Exhaust in Miners Study: A Nested Case–Control Study of Lung Cancer and Diesel Exhaust [letter]. Journal of National Cancer Institute (online first, DOI:10.1093/jnci/djs414).

  7. Tsoi Chi Tak, TSE Lap Ah*. Professional drivers and lung cancer: systematic review and meta-analysis. Occupational and Environmental Medicine (online first, doi:10.1136/oemed-2012-100666) [*Corresponding]

  8. Xie SH, Yu IT, Tse LA, Mang OW, Yue L. Sex difference in the incidence of nasopharyngeal carcinoma in Hong Kong 1983-2008: Suggestion of a potential protective role of oestrogen. Eur J Cancer. 2013 Jan,49(1):150-5. doi: 10.1016/j.ejca.2012.07.004. [*Corresponding]

  9. Tse Lap Ah, Chen MH, Au RKF, Wang F, Wang XR, Yu ITS. Pulmonary tuberculosis and lung cancer mortality in a historical cohort of workers with asbestosis. Public Health 2012,126:1013 -1016.

  10. TSE Lap Ah, YU Ignatius Tak-sun, WANG Xiao-rong, QIU Hong, AU Joseph Siu Kie. Synergistic Effect between Alcohol Consumption and Familial Susceptibility on Lung Cancer Risk among Chinese men. PLoS ONE 7(7): e40647. 2012. doi:10.1371/journal.pone.0040647.

  11. Tsoi Chi Tak, TSE Lap Ah*. Professional drivers and lung cancer: systematic review and meta-analysis. Occupational and Environmental Medicine, 2012 (doi:10.1136/oemed-2012-100666)[*Corresponding]

  12. CHEN Minghui, TSE Lap Ah*, AU Ronald, YU Tak Sun Ignatius, WANG Xiaorong, LAO Xiangqian and AU Joseph Siu-kie. Mesothelioma and lung cancer mortality: A historical cohort study among asbestosis workers in Hong Kong.  Lung Cancer. 2012,76(2):165-170.  [*Corresponding]

  13. Tse Lap Ah, Yu Ignatius Tak-sun, Qiu Hong, Au Joseph Siu Kai, Wang Xiao-rong. Occupational Risks and Lung Cancer Burden for Chinese Men: a Population-Based Case-Referent Study. Cancer Causes Control [DOI: 10.1007/s10552-011-9861-1].

  14. Tse Lap Ah, Ignatius Tak-sun Yu, Hong Qiu, Joseph Siu Kai Au, and Xiao-rong Wang. A Case-Control Study of Lung Cancer and Incense Smoke, Smoking and Residential Radon in Chinese Men. Environmental Health Perspectives2011,119:1641-1646.

  15. Tse Lap Ah, Ignatius Tak-sun YU, Hong QIU, Joseph Siu-kie AU, Xiao Rong WANG, Wilson TAM, and Kai Shing YU. Lung Cancer Decreased Sharply in First Five Years after Smoking Cessation in Chinese Men. Journal of Thoracic Oncology 2011,6:1670-1676.

  16. TSE Lap Ah, YU Ignatius Tak-sun, AU, Joseph Siu Kai, Qiu Hong, WANG Xiao-rong. Silica Dust, Diesel Exhaust, and Painting Work are the Significant Occupational Risk Factors for Lung Cancer in Chinese Nonsmoking Men. British Journal of Cancer 2011,104:208–213.

  17. TSE Lap Ah, YU Tak Sun Ignatius, GOGGINS III William Bernard, CLEMENT Mark, WANG Xiaorong, AU Joseph Siu-kie and YU Kai Shing.  Are current or future mesothelioma epidemics in Hong Kong the tragic legacy of uncontrolled use of asbestos in the past?.  Environmental Health Perspectives vol. 118. no. 3, pp.382-6, 2010.03.

  18. YIP Adrian Yun-san, TSE Lap Ah, ONG Eleanor Yuen-yuen and CHOW Louis Wing-cheong.  Survival benefits from lapatinib therapy in women with HER2-overexpressing breast cancer: a systematic review.  Anti-Cancer Drugs vol. 21 no. 5, pp. 487-93. 2010.06

  19. TSE Lap Ah, MANG Oscar Wai-kong, YU Tak Sun Ignatius, WU Fan, AU Joseph Siu-kie and LAW Stephen Chun-key.  "Cigarette Smoking and Changing Trends of Lung Cancer Incidence by Histological Subtype among Chinese Male Population".  Lung Cancer vol.66 no.1 pp.22-27. 2009.10.

  20. TSE Lap Ah, YU Tak Sun Ignatius, AU Joseph Siu-kie, YU Kai Shing, KWOK Kit Ping, QIU Hong and WONG Tze Wai. Environmental Tobacco Smoke and Lund Cancer among Chinese Nonsmoking Males: Might Adenocarcinoma be the Culprit?  American Journal of Epidemiology vol. 169 no. 5 pp 533-541, 2009.03.

  21. TSE Lap Ah, YU Tak Sun Ignatius and MANG Oscar W-k.  "Time trends of esophageal cancer in Hong Kong: Age, period and birth cohort analyses".  International Journal of Cancer vol.120 pp.853-858, 2007.02.15.

  22. YU Tak Sun Ignatius, TSE Lap Ah, LEUNG Chi Chiu, WONG Tze Wai, TAM Cheuck Ming and CHAN C. K. Alan.  "Lung cancer mortality among silicotic workers in Hong Kong—no evidence for a link".  Annals of Oncology vol.18 no.6, pp.1056-1063, 2007.06.

  23. TSE Lap Ah, YU Tak Sun Ignatius, MANG W. K. Oscar and WONG Siu Lan.  "Incidence rate trends of histological subtypes of nasopharyngeal carcinoma in Hong Kong".  British Journal of Cancer vol. 95 no.9, pp.1269-1273, 2006.11.06.

  24. YU Tak Sun Ignatius, TSE Lap Ah, WONG Tze Wai, LEUNG Chi Chiu, TAM Cheuk Ming and CHAN C K Alan.  "Further Evidence for a Link between Silica Dust and Esophageal Cancer".  International Journal of Cancer vol.114 pp.479-483, 2005.04.10.


COEHS experts

Wang XR, Associate Professor 
Ho KF, Assistant Professor
LaoXiangqian, Assistant Professor
Wang Feng, Research Assistant Profess
Wong TW, Research Professor


Specific topics of COEHS experts

  • Air pollution and health

  • Environmental exposures and cancer etiology (breast, lung, and prostate)

  • Night shift work and adverse health effects

  • Environmental air pollution and school health

  • Exposure assessment on air pollutants (PM2.5 and chemical components)

  • Occupational noise and deafness

  • Medical surveillance for dust exposed workers and cost-effective analysis

  • Occupational safety culture and tools development

  • Job exposure matrix development

  • Silicosis

  • Asbestosis

  • Mesothelioma

  • Dioxin exposure

  • Biomarkers and cancer genetics

  • Environmental health risk assessment