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Dr. Joseph Kai-man KAM (甘啟文醫生)

M.B., B.S., FRCPath 

Clinical Associate Professor, Stanley Ho Centre for Emerging Infectious Diseases


Personal Website:


Division of Infectious Diseases


Dr. Kam joined the Stanley Ho Centre for Emerging Infectious Diseases in 2015. He obtained his Diplomate in American Board of Medical Microbiology, and then worked extensively in different medical and public health laboratories. He had served in the editorial boards of Journal of Clinical Microbiology and the Federation of European Microbiological Societies (FEMS) Immunology and Medical Microbiology.

Dr. Kam conducts teaching in clinical and public health microbiology at undergraduate and postgraduate levels. He has served as external consultant to national and international organizations for laboratory capacity building (in planning, design, training, monitoring) and continuous quality improvement.

Research Interest

  • Molecular epidemiology using new laboratory tools, for tuberculosis;

  • Food and water borne pathogens with clinical and public health relevance;

  • Sexually transmitted diseases with local and regional significance;

  • Vector borne diseases that are emerging and/or re-emerging


Selected Publications 

  1. Nadon C, Van Walle I, Gerner-Smidt P, Campos J5, Chinen I, Concepcion-Acevedo J, Gilpin B, Smith AM, Kam KM, Perez E, Trees E, Kubota K, Takkinen J, Nielsen EM, Carleton H; FWD-NEXT Expert Panel. PulseNet International: Vision for the implementation of whole genome sequencing (WGS) for global food-borne disease surveillance. See comment in PubMed Commons below Euro Surveill. 2017 Jun 8;22(23). pii: 30544. doi: 10.2807/1560-7917.ES.2017.22.23.30544.

  2. Liang D, Leung RKK, Lee SS, Kam KM. Insights into intercontinental spread of Zika virus. PLoS One. 2017 Apr 27;12(4):e0176710. doi: 10.1371/journal.pone.0176710. eCollection 2017. PMID: 28448611

  3. Kwan TH, Lee SS, Chan DP, Cheung M, Kam KM. Assessing the risk of dengue virus transmission in a non-endemic city surrounded by endemic and hyperendemic areas.  Int J Infect Dis. 2017 Feb;55:99-101. doi: 10.1016/j.ijid.2017.01.008. Epub 2017 Jan 16. PMID: 28104506

  4. Cheng VW, Leung KS, Kwok JS, Leung RK, Yang KY, Chan RC, Kam KM, Tsui SK. Phylogenetic and Structural Significance of Dihydrofolate Synthase (folC) Mutations in Drug-Resistant Mycobacterium tuberculosis. Microb Drug Resist. 2016 Oct;22(7):545-551. Epub 2016 Apr 15. PMID: 27082669

  5. Chou KH, Kam KM, Ieong SK, Yip CW, Ip PK, Yew WW, Leung CC, Wong NS, Lau SM, Lee SS. Concurrent Outbreaks of Tuberculosis in a School and the Wider Community in Macau. J Pediatric Infect Dis Soc. 2015 Dec;4(4):359-62. doi: 10.1093/jpids/piu031. Epub 2014 Apr 30.  PMID: 26582875

  6. Cheng CK, Cheung MK, Nong W, Law PT, Qin J, Ling JM, Kam KM, Cheung WM, Kwan HS. Next generation genome sequencing reveals phylogenetic clades with different level of virulence among Salmonella Typhimurium clinical human isolates in Hong Kong. BMC Genomics. 2015 Sep 14;16:688. doi: 10.1186/s12864-015-1900-y. PMID: 26370680

  7. Barrera L, Cooreman E, de Dieu Iragena J, Drobniewski F, Duda P, Havelkova M, Hoffner S, Kam KM, Kim SJ, Labelle S, Lambregts K, Leimane V, Nunn P, Ramsay A, Raviglione M, Rich M, Ridderhof J, Rodrigues F, Rüsch-Gerdes S, Salfinger M, Scholten J, Selvakumar N, Shinnick T, Shul'gina M, Šķenders G, Sloutsky A, Small P, Van Deun A, Varaine F, Yagui M, Vincent V, Weyer K, Wright A, Zignol M. Policy Guidance on Drug-Susceptibility Testing (DST) of Second-Line Antituberculosis Drugs.  Geneva: World Health Organization; 2008. PMID: 26290924

  8. Li Q, Dong HY, Pang Y, Xia H, Ou XC, Zhang ZY, Li JC, Zhang JK, Huan ST, Chin DP, Kam KM, Zhao YL.  Multicenter Evaluation of the Molecular Line Probe Assay for Multidrug Resistant Mycobacterium Tuberculosis Detection in China.  Biomed Environ Sci. 2015 Jun;28(6):464-7. doi: 10.3967/bes2015.066. PMID: 26177909

  9. You JH, Lui G, Kam KM, Lee NL. Cost-effectiveness analysis of the Xpert MTB/RIF assay for rapid diagnosis of suspected tuberculosis in an intermediate burden area. J Infect. 2015 Apr; 70(4):409-14. doi: 10.1016/j.jinf.2014.12.015. Epub 2015 Jan 6. PMID: 25573001

  10. Li L, Wong HC, Nong W, Cheung MK, Law PT, Kam KM, Kwan HS. Comparative genomic analysis of clinical and environmental strains provides insight into the pathogenicity and evolution of Vibrio parahaemolyticus. BMC Genomics. 2014 Dec 18;15:1135. doi: 10.1186/1471-2164-15-1135.  PMID: 25518728

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