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Research &


Research Themes

Non-communicable Disease and Aging


Research Papers


  • Huang J., Lok V., Ngai C.H., Zhang L., Yuan J., Lao X.Q., Ng K., Chong C., Zheng Z.-J., Wong M.C.S.* (2021). Worldwide Burden of, Risk Factors for, and Trends in Pancreatic Cancer.  Gastroenterology, 160(3): 744-754

  • Tang H., Yang Z.-Y.*, Tang J.-L. (2021). β-Blocker and survival and pulmonary function in patients with chronic obstructive pulmonary and cardiovascular disease.  European heart journal, 42(12): 1180

  • Chong K.C., Chan E.Y.Y., Lee T.C., Kwok K.L., Lau S.Y.F., Wang P., Lam H.C.Y., Goggins W.B., Mohammad K.N., Leung S.Y., Chan P.K.S. (2021). A 21-year retrospective analysis of environmental impacts on paediatric acute gastroenteritis in an affluent setting.  Science of the Total Environment, 764:142845.

  • Huang J., Lok V., Ngai C.H., Chu C., Patel H.K., Thoguluva Chandraseka V., Zhang L., Chen P., Wang S., Lao X.-Q., Tse L.A., Xu W., Zheng Z.-J., Wong M.C.S. (2021). Disease Burden, Risk Factors, and Recent Trends of Liver Cancer: A Global Country-Level Analysis.  Liver Cancer, 10:330–345.

  • Sit R.W.S., Choi S.Y.K., Wang B., Chan D.C.C., Zhang D., Yip B.H.K., Wong S.Y.S. (2021). Neuromuscular exercise for chronic musculoskeletal pain in older people: A randomised controlled trial in primary care in Hong Kong.  British Journal of General Practice, 71(704): E226-E236.

  • Guo C., Yang H.T., Chang L.-Y., Bo Y., Lin C., Zeng Y., Tam T., Lau A.K.H., Hoek G., Lao X.Q. (2021). Habitual exercise is associated with reduced risk of diabetes regardless of air pollution: a longitudinal cohort study.  Diabetologia, 64(6): 1298-1308.

  • Lee P.M.Y., Tse L.A., László K.D., Wei D., Yu Y., Li J. (2021). Association of maternal body mass index with intellectual disability risk.  Archives of Disease in Childhood: Fetal and Neonatal Edition, 2021:fetalneonatal-2020-320793.

  • Guo C, Zeng YQ, Chang LY, Yu ZG, Bo YC, Lin CQ, Lau AKH, Tam T, Lao XQ (2020).  Independent and Opposing Associations of Habitual Exercise and Chronic PM2.5 Exposures on Hypertension Incidence. Circulation, 142(7):645–656.

  • Wang JJ, Huang LW, Gao Y, Wang YH, Chen SQ, Huang JJ, Zheng WJ, Bao PP, Gong YM, Zhang YF, Wang M, Wong MCS* (2020).  Physically active individuals have a 23% lower risk of any colorectal neoplasia and a 27% lower risk of advanced colorectal neoplasia than their non-active counterparts: systematic review and meta-analysis of observational studies.  British Journal of Sports Medicine, 54(10):582–591.

  • Guo C, Tam T, Bo YC, Chang LY, Lao XQ*, Thomas GN (2020).  Habitual physical activity, renal function and chronic kidney disease: a cohort study of nearly 200 000 adults.  British Journal of Sports Medicine, published online 11 January 2020.

  • Xia XX, Wu WKK, Wong SH, Liu D, Kwong TNY,  Nakatsu G, Yan PS, Chuang YM, Chan MWY, Coker O, Chen ZG, Yeoh YK, Zhao LY, Wang XS, Chen WY, Chan MTV, Chan PKS, Sung JJY, Wang MHT*, Yu J (2020).  Bacteria pathogens drive host colonic epithelial cell promoter hypermethylation of tumor suppressor genes in colorectal cancer.  Microbiome, 8:108.

  • Xia X, Qiu H, Kwok T, Ko FWS, Man CL, Ho KF* (2020).  Time course of blood oxygen saturation responding to short-term fine particulate matter among elderly healthy subjects and patients with chronic obstructive pulmonary disease.  Science of The Total Environment, 723:138022.

  • Lai FTT, Mercer SW, Guthrie B, Yip BHK, Chung GKK, Zou D, Lee EKP, Chau PYK, Chung RYN, Wong ELY, Yeoh EK, Wong SYS* (2020).  Sociodemographic moderation of the association between depression and stroke incidence in a retrospective cohort of 0.4 million primary care recipients with hypertension.  Psychological Medicine, published online 11 June 2020.

  • Sit RWS, Wu RWK, Rabago D, Reeves KD, Chan DCC, Yip BHK, Chung VCH, Wong SYS (2020).  Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial.  Annals of Family Medicine, 18(3):235–242.

  • Wong MCS, Huang JLW, George J, Huang JJ, Leung C, Eslam M, Chan HLY, Ng SC (2019).  The changing epidemiology of liver diseases in the Asia-Pacific region.  Nature Reviews Gastroenterology and Hepatology, 16(1):57–73.

  • Lao XQ, Deng HB, Liu XD, Chan TC, Zhang ZL, Chang LY, Yeoh EK, Tam T, Wong MCS, Thomas GN (2019).  Increased leisure-time physical activity associated with lower onset of diabetes in 44 828 adults with impaired fasting glucose: a population-based prospective cohort study.  British Journal of Sports Medicine, 53(14):895–900.

  • Tsoi KKF, Chan JYC, Chan FCH, Hirai HW, Kwok TCY, Wong SYS (2019).  Monotherapy Is Good Enough for Patients With Mild-to-Moderate Alzheimer's Disease: A Network Meta-Analysis of 76 Randomized Controlled Trials.  Clinical Pharmacology and Therapeutics, 105(1):121–130.

  • Wong MCS, Chan CH, Lin J, Huang JL, Huang J, Fang Y, Cheung WW, Yu CP, Wong JC, Tse G, Wu JC, Chan FK (2018).  Lower Relative Contribution of Positive Family History to Colorectal Cancer Risk with Increasing Age: A Systematic Review and Meta-Analysis of 9.28 Million Individuals.  American Journal of Gastroenterology, 113(12):1819–1827.

Research Grants


  • Recruit Breast Cancer Patients and Collect Clinical and Epidemiologic Data and Biospecimens

PI: Prof Shelly TSE

Sponsor: National Institutes of Health (NIH), National Cancer Institute (NCI), US Govt

Duration: 2018 – 2022


  • A Randomized Controlled Trial Evaluating Two e-Health Interventions (Presence/absence of Motivational Interviewing) in Increasing Colorectal Cancer Screening Among People Aged 50–60 with Moderate Risk

PI: Prof Joseph LAU

Sponsor: Food and Health Bureau (FHB) Health and Medical Research Fund (HMRF)

Duration: 2018 – 2021


  • Building Capacity to Promote Winter Health in Elderly: Co-production of a Volunteer-based Home Care Programme for Post-discharged Elderlies by Medical-social-academic Sector

PI: Prof Eliza WONG

Sponsor: Food and Health Bureau (FHB) Health Care and Promotion Scheme (HCPS)

Duration: 2018 – 2020


  • Adoption of a drug adherence-enhancing application to achieve optimal medication adherence and blood pressure control among hypertensive patients: a community-based intervention programme

PI: Prof Martin WONG

Sponsor: Food and Health Bureau (FHB) Health Care and Promotion Scheme (HCPS)

Duration: 2019 – 2021


  • Combining mind-body physical exercise, cognitive training, and nurse-led risk factor modification to enhance cognition among older adults with mild cognitive impairment: a randomized controlled trial

PI: Prof Samuel WONG

Sponsor: Food and Health Bureau (FHB) Health and Medical Research Fund (HMRF)

Duration: 2019 – 2022


  • The risk of advanced colorectal neoplasia according to the length of the period of surveillance colonoscopy: a multi-centre colonoscopy trial

PI: Prof Martin Wong

Sponsor: Research Grants Council (RGC) General Research Fund (GRF)

Duration: 2020 – 2022

  • The risk of advanced neoplasia within subcentimetric polyps detected in colorectal cancer screening participants in Chinese populations: a multi-centre colonoscopy study


PI: Prof Martin WONG

Sponsor: Research Grants Council (RGC) General Research Fund (GRF)

Duration: 2021 – 2023

  • Exploring the role of self-compassion in self-management behaviors among Type 2 diabetes patients in Hong Kong: a longitudinal study

PI: Prof Nelson YEUNG

Sponsor: Research Grants Council (RGC) Early Career Scheme (ECS)

Duration: 2021 – 2022

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