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​Professor Paul Kay-sheung CHAN


MBBS (HK), MSc, MD (CUHK), FRCPath, FHKCPath, FHKAM (Pathology)


Email: paulkschan@cuhk.edu.hk


ORCID: 0000-0002-6360-4608

ResearcherID: J-9360-2013
Loop profile: 293427

Academic Appointments

  • Chairman, Department of Microbiology, Faculty of Medicine, Chinese University of Hong Kong

  • Deputy Director, Stanley Ho Centre for Emerging Infectious Diseases, Faculty of Medicine, Chinese University of Hong Kong

  • Visiting Professor of College of Life Science and Bioengineering, Beijing University of Technology

  • Member of the Global Outbreak Alert and Response Network of World Health Organization
    Examiner of the Hong Kong College of Pathologists


Professor Paul Chan is Clinical Professor and Chairman of the Department of Microbiology, and Deputy Director of the Stanley Ho Centre for Emerging Infectious Diseases, Faculty of Medicine, The Chinese University of Hong Kong. He is also Honorary Consultant in Microbiology for the New Territories East Cluster Hospitals of Hong Kong Hospital Authority. Professor Chan is a renowned clinical virologist with special interest in tumour virology, human respiratory viruses and microbiome. He serves many key professional bodies in Hong Kong, including the Scientific Committee on Emerging and Zoonotic Diseases of the Centre for Health Protection, the Grant Review Board for Medical and Health Research Fund, the Hong Kong College of Pathologists Examiner Committee. Professor Chan is also a partner of the Global Outbreak Alert and Response Network He is Editor-in-Chief of the Journal of Virological Methods. Professor Chan has published 14 book chapters and more than 350 scientific papers, and attained an H-index of 53.

Research Interests

  • Clinical management of emerging respiratory infections

  • The safety of respiratory therapy in the post SARS era

  • The efficacy of the medical ward airflow in preventing nosocomial infections

  • Sleep disordered breathing and common airway diseases

Selected Publications

  1. Zhang C, Luo Y, Zhong R, Law PTY, Boon SS, Chen Z, Wong CH, Chan PKS. Role of polycyclic aromatic hydrocarbons as a co-factor in human papillomavirus-mediated carcinogenesis. BMC Cancer 2019; 19: 138.

  2. Law PT, Boon SS, Hu C, Lung RW, Cheung GP, Ho WC, Chen Z, Massimi P, Thomas M, Pim D, Banks L, Chan PKS. Oncogenic comparison of human papillomavirus type 58 E7 variants. Journal of Cellular Molecular Medicine 2019; 23: 1517-1527.

  3. Lai TO, Boon SS, Law PT, Chen Z, Thomas M, Banks L, Chan PKS. Oncogenicitiy comparison of human papillomavirus type 52 E6 variants. Journal of General Virology 2019; 100: 484-496.

  4. Zuo T, Lu XJ, Zhang Y, Cheung CP, Lam S, Zhang F, Tang W, Ching JYL, Zhao R, Chan PKS, Sung JJY, Yu J, Chan FKL, Cao Q, Sheng JQ, Ng SC. Gut mucosal virome alterations in ulcerative colitis. Gut 2019; 68: 1169-1179.

  5. Yeoh YK, Chen Z, Hui M, Wong MCS, Ho WCS, Chin ML, Ng SC, Chan FKL, Chan PKS. Impact of inter- and intra-individual variation, sample storage and sampling fraction on human stool microbial community profiles. PeerJ 2019; 7: e6172. 

  6. Zuo T, Wong SH, Cheung CP, Lam K, Lui R, Cheung K, Zhang F, Tang W, Ching JYL, Wu JCY, Chan PKS, Sung JJY, Yu J, Chan FKL, Ng SC. Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection. Nature Communications 2018; 9: 3663. 

  7. Nakatsu G, Zhou H, Wu WKK, Wong SH, Coker OO, Dai Z, Li X, Szeto CH, Sugimura N, Lam TY, Yu AC, Wang X, Chen Z, Wong MC, Ng SC, Chan MTV, Chan PKS, Chan FKL, Sung JJ, Yu J. Alterations in enteric virome are associated with colorectal cancer and survival outcomes. Gastroenterology 2018; 155: 529-541.

  8. Zuo T, Wong SH, Lam K, Lui R, Cheung K, Tang W, Ching JYL, Chan PKS, Chan MCW, Wu JCY, Chan FKL, Yu J, Sung JJY, Ng SC. Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome. Gut 2018; 67: 634-643.

  9. Chan MCW, Wang MH, Chen Z, Hui DSC, Kwok AK, Yeung ACM, Liu KM, Yeoh YK, Lee N, Chan PKS. Frequent Genetic Mismatch between Vaccine Strains and Circulating Seasonal Influenza Viruses, Hong Kong, China, 1996-2012. Emerging Infectious Diseases 2018; 24: 1825-1834.

  10. Yeung KHT, Chan KCC, Chan PKS, Lam DSY, Sham PCO, Yau YS, Chan WH, Chiu WK, Ng KL, Ng DKK, Chan IMC, Nelson EAS. Influenza vaccine effectiveness in hospitalised Hong Kong children: Feasibility of estimates from routine surveillance data. Vaccine. 2018; 36: 3477-3485. 

Last Updated: 22 July 2020

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