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Academic Staff
​Prof. Benjamin Hon-kei YIP 葉漢基教授

Prof. Benjamin Hon-kei YIP


BSc (Örebro University, Swe), PhD (Karolinska Institutet, Swe)

Associate Professor


Dr. Yip joined the School of Public Health and Primary Care (SPHPC) of the Chinese University of Hong Kong (CUHK) in 2011, and he is currently an Assistant Professor. In 2008, he received his Doctor of Philosophy (PhD) degree from Karolinska Institutet, Sweden. His thesis was to develop statistical methods for estimating random effects models with the purpose of estimating variance components for disease liability and correlations in pedigree data. Together with his PhD supervisor, Professor Yudi Pawitan, they examined the co-morbidity and liability between schizophrenia and bipolar disease in a large population based sample⁠. This research ended one of the most persistent debate in psychiatry which is whether schizophrenia and bipolar disorder are the clinical realizations of entirety different versus identical etiological process (Lancet 2009). He continued to develop and refine these methods, as evident by recent publications in top international peer review manuscripts⁠ (JAMA Psychiatry 2019 , Biological Psychiatry 2018, 2020).

In parallel with his continued engagement at Karolinska Institutet on genetic epidemiological research, he is serving as the lead statistician in various clinical studies, ranging from clinical trials to cohort studies, steering committee member of Domestic Health Account (FHB), member of service learning committee (Chung Chi College), and a leading member of one WUN working group on integrated care model for multimorbidity. He is teaching health economics both on bachelor and post-graduate level. He is currently supervising four PhD students. Previously, he supervised/co-supervised four other graduated PhD students.

Dr. Yip is serving as the principal investigators or as the lead biostatistician in numerous funded projects (see below). He has 83 academic articles (up-to-date 20/07/2020) with a h-index of 17. For a complete publications list please see

Research Interests

  • Mental Health: Epidemiology and genetic epidemiology of autism spectrum disorder

  • eHealth: wearables, monitoring, behaviour

  • Health Economics: trial-based economic evaluation

Recent Funded Research Projects 

  • As Principal Investigator or Co-Principal Investigator

    • Sex Differences in Autism Spectrum Disorder: A Population-based Genetic Epidemiological Study. (ECS24108520, 2020)

    • The Hong Kong Mental Morbidity Survey for Older People – HKMMSOP (FHB, 2019-2022)

    • Post-discharge health care utilization and needs among young stroke patients: a prospective cohort study (CUHK Direct Grant 143386979, 2020-2021)

    • Integrating Health & Social Care Services to Tackle Asia’s Ageing Population & Rise in Chronic & Multi- Morbidity: Global Developments & Lessons (WUN RDF 4930631, 2020 – 2021)


  • As Co-Investigator

    • Effectiveness of a Complex Exercise Intervention to Normalize Blood Pressure and Its Nocturnal Dipping in Patients with Hypertension in Primary Care: A Randomized-controlled Trial (Co-I, HMRF136636363, 2020-2023)

    • Novel Retinal Imaging Biomarkers for Children Amblyopia (Co-I, HMRF136635437, 2020-2023)

    • Preventing Curve Progression and the Need for Bracing in Early Diagnosed Adolescent Idiopathic Scoliosis Using Calcium Plus Vitamin D Supplementation – A Randomized Double-blinded Placebo-controlled Trial (Co-I, GRF138172334, 2018-2023)

    • Low-Concentration Atropine for Myopia Progression (LAMP) Phase 4 Study: 5-year follow up to evaluate the optimal treatment regimen and long-term efficacy of low-concentration atropine eye drops (GRF138277701, 2020-2022)

    • Incidence, Clinical Presentation, Treatment Modalities, and Long Term Outcomes of Retinoblastoma in Hong Kong: Hong Kong Retinoblastoma Registry (HMRF136630353, 2020-2022)

    • Tender for the Provision of Services of the Monitoring and Evaluation Study of Kwai Tsing District Health Centre (FHB136603387, 2019-2022)

    • Combining Mind-body Physical Exercise, Cognitive Training, and Nurse-led Risk Factor Modification to Enhance Cognition among Older Adults with Mild Cognitive Impairment: A Randomized Controlled Trial (HMRF136562162, 2019-2022)

    • Complex Interventions for Reducing 30-day Avoidable Hospital Readmission among Adults: Recommendations for Hong Kong via Overview of Systematic Reviews and Stakeholder Consensus (HMRF136561236, 2019-2022)

    • Vibration Therapy as a Primary Prevention Strategy of Fragility Fracture, a Local Invention for the Local Community (Research Committee Group Research Scheme CUHK 136553354, 2020-2021)

    • Do Women with a History of Recurrent Miscarriage Have a Higher Risk of Obstetric and Perinatal Complications in a Subsequent Pregnancy? A Cohort Study (HMRF136594341, 2020-2021)

    • The Feasibility and Effects of Mindfulness Based Relapse Prevention (MBRP) on Reducing Craving and Addictive Behaviour in Local Adults with Substance Abuse Disorders (Beat Drugs Fund 136611718, 2019-2021)

    • Exposure to Alcohol Social Media Marketing and Associations with Young Adult''s Drinking Expectancies and Behaviours: A Study to Inform Regulation and Health Promotion (HMRF136628500, 2020-2021)

    • The Effect of Virtual Reality Phacoemulsification Cataract Extraction Simulation Surgery Training on Patient Safety and Outcomes: A Randomised Controlled Trial (VRPhaco Sim Study) (HMRF136434203, 2018-2021)

    • The effects of a mindfulness based intervention - MYmind - for children with ADHD and their parents: a randomised controlled trial (HMRF 138201888, 2018-2020)

    • Building Capacity to Promote Winter Health in Elderly: Co-production of a Volunteer-based Home Care Programme for Post-discharged Elderlies by Medical-social-academic Sector (HCPS 136453631, 2018-2020)

    • Harms and Second-hand Harms of Alcohol Consumption in Hong Kong: A Population-based Study to Inform Public Policy (HMRF136572358, 2019-2020)

    • Feasibility and Acceptability of World Health Organization’s “Best Buys” for Reducing the Harms of Alcohol Use in Hong Kong: Comparison of Population Attitudes and Stakeholder''s Opinions. (GRF 138207457, 2017-2020)

Selected Publications

  1. Bai D, Marrus N, Yip BHK, Reichenberg A, Constantino JN, Sandin S. Inherited Risk for Autism Through Maternal and Paternal Lineage. Biol Psychiatry. 2020 Apr 2:S0006-3223(20)31384-6. doi:10.1016/j.biopsych.2020.03.013.

  2. Bai D, Yip BHK, Windham GC, Sourander A, Francis R, Yoffe R, Glasson E, Mahjani B, Suominen A, Leonard H, Gissler M, Buxbaum JD, Wong K, Schendel D, Kodesh A, Breshnahan M, Levine SZ, Parner ET, Hansen SN, Hultman C, Reichenberg A, Sandin S. Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort. JAMA Psychiatry. 2019 Jul 17;. doi: 10.1001/jamapsychiatry.2019.1411.

  3. Yip BHK*, Bai D, Mahjani B, Klei L, Pawitan Y, Hultman CM, Grice DE, Roeder K, Buxbaum JD, Devlin B, Reichenberg A, Sandin S. Heritable Variation, With Little or No Maternal Effect , Accounts for Recurrence Risk to Autism Spectrum Disorder in Sweden. Biological Psychiatry. 2018;83:589–97.

  4. Yip BHK*, Leonard H, Stock S, Stoltenberg C, Francis RW, Gissler M, Gross R, Schendel D, Sandin S. Caesarean section and risk of autism across gestational age: a multi-national cohort study of 5 million births. International Journal of Epidemiology. 2017;46:429-439.

  5. Lichtenstein P, Yip BH, Björk C, Pawitan Y, Cannon TD, Sullivan PF, Hultman CM. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. The Lancet. 2009;373:234-9.

  6. Yip BH, Pawitan Y, Czene K. Parental age and risk of childhood cancers: A population-based cohort study from Sweden. International Journal of Epidemiology. 2006;35:1495-503

Last Updated: 22 July 2020

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