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Professor Benny Chung-ying ZEE (徐仲鍈教授)

Bsc, Msc (Manit.) PhD (Pitt.)

Associate Director (Graduate Studies) and Head, Division of Biostatistics

JC School of Public Health and Primary Care


Director, Centre for Clinical Research and Biostatistics

Email: bzee@cuhk.edu.hk

Division

Division of Biostatistics

Biography

Professor Benny Zee is a Professor of the Jockey Club School of Public Health and Primary Care heading the Division of Biostatistics. He has over 20 years of clinical trials experience. He holds honorary appointments in the Department of Clinical Oncology and the Department of Statistics of CUHK. Professor Zee obtained his PhD in Biostatistics from the University of Pittsburgh USA in 1987. He then joined the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) as Senior Biostatistician, and faculty member in the Department of Community Health and Epidemiology and the Department of Mathematics and Statistics of Queen's University Canada from 1987-2001. 

Professor Zee has strong interest in various aspects of multi-center clinical trials, including statistical methods and data management. He is active in biostatistics research, especially in the area of bioinformatics, quality of life, phase II/III trials design, data & safety monitoring and other statistical issues related to clinical trials. He has experience in the development of efficient data management procedure using advanced computer technology, plus ample experience in working with industry to design and carry out clinical trials that satisfy both academic and industry interests.

Research Interest

  • Clinical trials methodology - Design of phase II/III clinical trials with multiple endpoints; Interim analysis issues; Randomized phase II design for hepatocellular cancer (HCC) trials.

  • Biostatistics Methodology: Quality of life analysis with missing data; survival analysis.

  • Bioinformatics analysis – Wavelet-based approach to analyze microarray data; Analysis of array-CGH data; Prognostic modeling with gene expression.

  • Ethical issues in clinical research.

  • Data management in clinical trials - remote data entry.

 

Selected Publications 

  1. Chan, K.C.A, Woo, J.K.S., King, A., Zee, B.C.Y., Lam, W.K.J., Chan, S.L., Chu, S.W.I., Mak, C., Tse, I.O.L., Leung, S.Y.M., Chan, G., Hui, E.P., Ma, B.B.Y., Chiu, R.W.K., Leung, S.-F., Van Hasselt, A.C., Chan, A.T.C., Lo, Y.M.D. “Analysis of plasma Epstein–Barr virus DNA to screen for nasopharyngeal cancer”, New England Journal of Medicine, Volume 377, Issue 6, 10 August 2017, Pages 513-522

  2. Zee B, Lee J, Li Q, “Method and device for retinal image analysis”, US Non-Provisional Patent No. US8787638 B2, granted on 22 July 2014; Taiwan Patent “视网膜图像分析装置”, Patent No. I578977 granted on 21 April 2017; China Patent “视网膜图像分析方法和装置”, Patent No. 2017071100061980, granted on 14 July 2017

  3. Wang MH, Lau SYF, Chong KC, Kwok C, Lai M, Chung HY, Ho CS, Szeto CC, Zee B. “Estimation of clinical parameters of chronic kidney disease (CKD) by exhaled breath full-scan mass spectrometry data and Iterative PCA with Intensity Screening (IPS) algorithm”. J Breath Res. 2017 Jun 1. doi: 10.1088/1752-7163/aa7635.

  4. Zhuo Y, Yu H, Yang Z, Zee B, Lee J, Kuang L “Prediction Factors of Recurrent Stroke among Chinese Adults Using Retinal Vasculature Characteristics”, J Stroke Cerebrovasc Dis. Volume 26, Issue 4, 1 April 2017, Pages 679-685

  5. Chong KC, Zhang C, Zee BC, Luo T, Wang L, Tam GC, Jia KM, Sun R, Wang MH, Guan X. “Interpreting the transmissibility of measles in two different post periods of supplementary immunization activities in Hubei, China”, Vaccine. 2017 Feb 15;35(7):1024-1029. doi: 10.1016/j.vaccine.2017.01.010. Epub

  6. Wang MH, Chang B, Sun R, Hu I, Xia X, Wu WKK, Chong KC, Zee BC, “Stratified polygenic risk prediction model with application to CAGI bipolar disorder sequencing data”, Hum Mutat. 2017 Apr 17. doi: 10.1002/humu.23229. [Epub ahead of print]

  7. Wang MH, Chong KC, Storer M, Pickering JW, Endre ZH, Lau SY, Kwok C, Lai M, Chung HY, Ying Zee BC, “Use of a least absolute shrinkage and selection operator (LASSO) model to selected ion flow tube mass spectrometry (SIFT-MS) analysis of exhaled breath to predict the efficacy of dialysis: a pilot study”, J Breath Res. 2016 Sep 28;10(4):046004. doi: 10.1088/1752-7155/10/4/046004.

  8. Zee B., Lee J., Li Q., Mok V., Kong A., Chiang L.K., Ng L., Zhuo Y., Yu H., Yang Z. “Stroke risk assessment for the community by automatic retinal image analysis using fundus photograph, Quality in Primary Care (2016) 24 (3): 114-124

  9. Lai X and Zee B, "Mixed response and time-to-event endpoints for multistage single-arm phase II design", Trials 2015, 16:250, DOI: 10.1186/s13063-015-0743-9

  10. Lee J, Zee B, Li Q, “Detection of Neovascularization based on Fractal and Texture Analysis with Interaction Effects in Diabetic Retinopathy”,  PLoS One. 2013 Dec 16;8(12):e75699. doi: 10.1371/journal.pone.0075699

Publication Summary

(As obtained from Scopus ID: 7006378172)

Total no. of publications:  220

Total citations:                    18114

H-index for all years:         70

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