Discover the transformative potential of adaptive platform trials in primary care, a groundbreaking approach offering efficient and rigorous solutions to pressing patient-centered questions. Unlike traditional trials, adaptive platform trials enable dynamic adjustments to trial aspects and statistical procedures without compromising validity or integrity. This lecture will explore the dynamic world of platform trials, specifically their ability to simultaneously test multiple treatments for the same disease. Additionally, the presentation will highlight the flexibility of platform trials in accommodating new treatments and swiftly eliminating futile interventions through frequent interim analyses. Drawing on examples from actual clinical trials, such as the ALIC4E trial for oseltamivir in influenza and the PRINCIPLE and PANORAMIC trials for repurposed drugs and novel antivirals in COVID-19, this lecture will illustrate the unique features and potent capabilities of platform adaptive trials in primary care research.
Join us for an insightful one-hour lecture featuring Prof. Christopher Butler, an esteemed researcher with notable contributions to prestigious journals such as The Lancet. This session will delve into the cutting-edge realm of adaptive platform trial design, a topic at the forefront of clinical research. Attendees will gain valuable insights into the innovative methodologies shaping the future of clinical trials. Don't miss this opportunity to deepen your understanding of adaptive platform trials and their impact on advancing medical research.
Exploring the Methodology of Adaptive Platform Trials
Date: | 27 February 2024 (Tuesday) |
Time: | 1:00 – 2:00 pm |
Venue: | KCTCRC, 1/F, School of Public Health Building, Prince of Wales Hospital |
Speaker: | Prof. Chris Butler Professor of Primary Care, Nuffield Department of Primary Care Health Sciences, University of Oxford |
Moderator: | Prof. Regina Sit Associate Professor (Clinical), The JC School of Public Health and Primary Care, The Chinese University of Hong Kong |
About the speaker:
Professor Chris Butler is Professor of Primary Care in the Nuffield Department of Primary Care Health Sciences. His research focuses on common infections (especially the appropriate use of antimicrobials, antimicrobial resistance, point of care testing, and treatments for viral infections), and health care communication and behaviour change (co-author of Motivational Interviewing in Health Care).
Prof. Butler is also Co-Chief Investigator of the PRINCIPLE and PANORAMIC adaptive, platform, randomised, controlled trials of community treatments for COVID 19, that have recruited >38,000 participants and evaluated 9 medicines so far.
Prof. Butler has published >500 papers and led or helped lead ~30 randomised clinical trials, and has recently published trial results in the world’s top three general medical journals. His H-Index is >60. His PACE Study won the Royal College of General Practitioners Research Paper of the Year Award in 2020.
About the moderator:
Professor Regina Sit is the Associate Professor (Clinical) of the Jockey Club School of Public Health and Primary Care, the Chinese University of Hong Kong. She obtained her MBBS degree from the University of Hong Kong and became a Family Medicine Specialist since 2011. In addition to her specialist training, she develops her special skills in pain management and is a Certified Interventional Pain Sonologist by the World Institute of Pain. Regina obtained her Doctor of Medicine research degree in 2020. Regina is a clinician-scientist with her clinical and research work focus on chronic musculoskeletal pain in primary care. She has a strong publication track records and her studies have been published in top-tier Primary care journals, Pain journals and Orthopaedic journals, such as Annals of Family Medicine, British Journal of General Practice, Pain, and Osteoarthritis and Cartilage. Her contributions to osteoarthritis research resulted in appointment to the Lancet Commissioner on Osteoarthritis in August 2020 as a content expert speaking for primary care physicians in the Asia region. Currently, she is the Director of the “CUHK-Jockey Club Confront Pain with Ease Project” and is leading an interdisciplinary team for chronic pain management in primary care.