学院教职员

教学人员

王海天教授

Prof. Maggie Haitian WANG

BSc (HKUST), PhD (HKUST) 

助理教授

学术委任

  • 香港中文大学流行病学及生物统计学硕士课程联席负责人

  • 《人类遗传学》审稿编辑

个人简介

王海天教授毕业于香港科技大学,获物理学学士(荣誉)及统计学博士学位。她于2011年加入中大,担任研究助理教授,后于2015年担任助理教授。王教授曾于2010年和2016年分别在哥伦比亚大学和斯坦福大学做访问学者。王博士是GRF、NSFC和HMRF基金的首席研究员。王教授是《人类遗传学》杂志的审稿编辑,以及国际遗传流行病学会科学项目和交流委员会的成员。

研究方向

王海天博士的研究重点是统计遗传学和生物信息学,主要有传染病基因组和人类基因组解读两大应用领域。在人类基因组方面,王教授的课题组开发了新的统计方法和工具,用于识别疾病易感生物标志物,提高疾病预测准确率。在流感基因组研究方面,王教授课题组提出了连通遗传学和流行病学的新方法,捕捉病毒突变模式,实现疫苗抗原优化。

近期获资助研究项目

  • PI, Health and Medical Research Fund (HMRF) commissioned research on the Novel Coronavirus Diseases (COVID-19): Characterizing whole genome stability of the novel coronavirus SARS-CoV-2. PI: Maggie Wang, 2020/04/01 – 2023/03/31

  • PI of sub-project, Health and Medical Research Fund (HMRF) 2018/19, Sub-project title: Real-time surveillance of influenza viral evolution and antigenic mutation estimation, 01/09/2019 – 31/08/2022

  • PI, National Natural Science Foundation of China (NSFC) – General Project, Improving prediction accuracy of Alzheimer's Disease by Incorporating a novel feature selection method, 01/01/2019/ - 31/12/2022

  • PI, National Natural Science Foundation of China (NSFC) – General Project, Tracking pattern of amino acids underlying seasonal influenza, 01/01/2015 – 31/12/2018

部份学术文章

  1. Xiaoxuan Xia, William K.K. Wu, Sunny H. Wong, Dabin Liu, Thomas N.Y. Kwong, Geicho Nakatsu, Pearlly S. Yan, Yu-Ming Chuang, Michael W.Y. Chan, Olabisi O. Coker, Zigui Chen, Yun K. Yeoh, Liuyang Zhao, Xiansong Wang, Wing Y. Cheng, Matthew T.V. Chan, Paul K.S. Chan, Joseph J.Y. Sung, Maggie H Wang*, Jun Yu* (2020) (co-corresponding author) Bacteria pathogens drive host colonic epithelial cell promoter hypermethylation of tumor suppressor genes in colorectal cancer. Microbiome. IF=10.465, Rank 7/149 in Microbiology

  2. Chan MC, Wang MH, Chen Z, Hui DS, Kwok AK, Yeung AC, Liu KM, Yeoh YK, Lee N, Chan PK. Frequent Genetic Mismatch between Vaccine Strains and Circulating Seasonal Influenza Viruses, Hong Kong, China, 1996–2012. Emerging infectious diseases. (2018) Oct;24(10):1825. IF = 8.22. Rank 3/84

  3. Maggie Haitian Wang*, Haoyi Weng+, Rui Sun, Jack Lee, William Ka Kei Wu, Ka Chun Chong, Benny Chung-Ying Zee (2017) A Zoom-Focus Algorithm (ZFA) to locate the optimal testing region for rare variant association tests. Bioinformatics, IF=7.2. Corresponding author

  4. Maggie Haitian Wang, Rui Sun, Junfeng Guo, Haoyi Weng, Jack Lee, Inchi Hu, Pak Sham and Benny Chung-Ying Zee (2016). A fast and powerful W-test for pairwise epistasis testing. Nucleic Acids Research. IF=11.6.

  5. Rui Sun, Haoyi Weng, Inchi Hu, Junfeng Guo, William K.K. Wu, Benny Chung-Ying Zee, Maggie Haitian Wang* (2016) A W-test collapsing method for rare variant association testing in exome sequencing data. Genetic Epidemiology. DOI: 10.1002/gepi.22000.

  6. Maggie Haitian Wang*, Billy Chang, Rui Sun, Inchi Hu, Marc Ka Chun Chong, Benny Chung Ying Zee (2017), A Stratified Polygenic Risk Prediction Model with Application on CAGI Bipolar Disorder Sequencing Data. Human Mutation. 2017 Sep;38(9):1235-9. Rank 24/171 in Genetics & Heredity Science. IF=5.359. https://doi.org/10.1002/humu.23229

  7. Maggie Haitian Wang*, Heather Cordell, Kristel Van Steen (2019) Statistical Methods for Genome-wide Association Studies. Seminars in Cancer Biology. 2019 April. Rank 13/223 in Oncology. IF = 10.198 Doi: 10.1016/j.semcancer.2018.04.008

  8. Xiaoxuan Xia, Haoyi Weng, Rui Sun, Ka Chun Chong, Benny Chung Ying Zee*, Maggie Haitian Wang* Incorporating methylation genome information improves prediction accuracy for drug treatment responses. BMC Genetics. 2018 Sep;19(1):78. IF = 2.569 Doi: 10.1186/s12863-018-0644-5 (supervisor of the first author)

  9. Maggie Haitian Wang+, Ka Chun Chong+, Hau Yin Chung, Malina Storer, John Pickering, Zoltan Endre, Steven Lau, Chloe Kwok, Maria Lai, Benny Zee (2016). Use of a Least Absolute Shrinkage and Selection Operator (LASSO) Model to Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) Analysis of Exhaled Breath to Predict the Efficacy of Dialysis. Journal of Breath Research 10 (2016) 046004.

  10. Maggie Haitian Wang, Shaw-Hwa Lo, Tian Zheng and Inchi Hu (2012) A Classification Method Incorporating Interactions among Variables for High-dimensional Data. Bioinformatics (2012) 28 (21): 2834-2842

Last Updated: 22 July 2020

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